One of the most widely studied aspects of floatation is how it can be used as a tool to help people with anxiety and/or depression   . There have been several studies that focussed on individuals with clinical anxiety, including: generalized anxiety disorder, post-traumatic stress disorder (PTSD), anorexia nervosa, panic disorder, agoraphobia, and social anxiety disorder  .
These studies have indicated that floatation can be a powerful tool for helping with these conditions in conjunction with traditional medicines and therapy.
Just being able to be in an environment where external stimuli can be shut out is very beneficial for removing the usual external triggers of stress and anxiety, which provides a chronically anxious or hypervigilant person a rare respite from the barrage of those triggers they normally experience in everyday life.
: Preventing Sick-leave for Sufferers of High Stress-load and Burnout Syndrome: A Pilot Study Combining Psychotherapy and the Flotation tank (Anette Kjellgren, Hanne Buhrkall and Torsten Norlander)
 Bending and Mending the Neurosignature: Frameworks of influence by flotation-REST (Restricted Environmental Stimulation Technique) upon well-being in patients with stress related ailments (Bood, Sven-Åke)
 Psychotherapeutic Treatment in Combination with Relaxation in a Flotation Tank: Effects on “Burn-Out Syndrome” (Anette Kjellgren, Hanne Buhrkall, Torsten Norlander)
 The Elicitation of Relaxation and Interoceptive Awareness Using Floatation Therapy in Individuals with High Anxiety Sensitivity (Justin S. Feinstein, Sahib S. Khalsa, Hung Yeh, Obada Al Zoubi, Armen C. Arevian, Colleen Wohlrab, Marie K. Pantino, Laci J. Cartmell, W. Kyle Simmons, Murray B. Stein, and Martin P. Paulus)
 Reduced Environmental Stimulation in Anorexia Nervosa: An Early-Phase Clinical Trial (Sahib S. Khalsa, Scott E. Moseman, Hung-Wen Yeh, Valerie Upshaw, Beth Persac, Eric Breese, Rachel C. Lapidus, Sheridan Chappelle, Martin P. Paulus and Justin S. Feinstein)
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