One of the most widely studied aspects of floatation is how it can be used as a tool to help people with anxiety and/or depression. There have been several studies that focussed on individuals with clinical anxiety, and in most cases the participants also suffered from comorbid unipolar depression    (whilst depression and anxiety are sperate conditions, it is very common for people to suffer from a mix of anxiety and depression  – around 58% of people diagnosed with depression were also diagnosed with anxiety in one US study).
These studies have indicated that floatation can be a powerful tool for helping with these conditions in conjunction with traditional medicines and therapy. Results from these studies show significant reductions in state of anxiety, stress, muscle tension, pain and depression, while at the same time showing a substantial improvement in mood (characterised by increases in serenity, relaxation, happiness, positive effect, overall wellbeing, energy levels, and feeling refreshed, content and peaceful).
: Preventing Sick-leave for Sufferers of High Stress-load and Burnout Syndrome: A Pilot Study Combining Psychotherapy and the Flotation tank (Anette Kjellgren, Hanne Buhrkall and Torsten Norlander)
 Bending and Mending the Neurosignature: Frameworks of influence by flotation-REST (Restricted Environmental Stimulation Technique) upon well-being in patients with stress related ailments (Bood, Sven-Åke)
 Psychotherapeutic Treatment in Combination with Relaxation in a Flotation Tank: Effects on “Burn-Out Syndrome” (Anette Kjellgren, Hanne Buhrkall, Torsten Norlander)
 Depression and Anxiety-Separate or Continuum? (Siegfried Kasper)
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